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Munich (DE) / Vienna (AT), 7 June 2022 Viscovery and Biomax are introducing an analysis pipeline for longitudinal brain morphometry studies

Together with our colleagues from Biomax Informatics, we published the article Automated High-Definition MRI Processing Routine Robustly Detects Longitudinal Morphometry Changes in Alzheimer’s Disease Patients in Frontiers in Aging Neuroscience.

In this article a profound analysis pipeline for longitudinal MRI studies is proposed. It uses state-of-the-art methods for neuro-imaging, segmentation and statistical assessments. A case study with Alzheimer’s disease patients and a control group of age-related cognitively normal subjects from the ADNI-3 study was conducted to test the pipeline which was fully implemented in Biomax’ neuro-imaging solution NICARA.

Find the full open access article at www.frontiersin.org.

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Horn (NL) / Vienna (AT), 21 February 2022 Viscovery profiles outcomes to bronchodilator therapy

Together with Maud Koopman and her colleagues from our long term customer CIRO+, we published the article Differential Outcomes Following 4 Weeks of Aclidinium/Formoterol in Patients with COPD: A Reanalysis of the ACTIVATE Study in the International Journal of Chronic Obstructive Pulmonary Disease.

The ACTIVATE study is a randomized, double-blind and placebo-controlled study investigating the effects of aclidinium bromide / formoterol fumarate bronchodilator therapy on lung hyperinflation and physical exercise capabilities. The outcome data on lung function and physical exercises were clustered with Viscovery SOMine to find typical outcome profiles and assess the impact of bronchodilator therapy.

Find the full open access article at www.dovepress.com

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Horn (NL) / Vienna (AT), 17 February 2022 Finding response predictors with Viscovery SOMine Together with Ingrid Augustin and her colleagues from our long term customer CIRO+, we published the article Multidimensional outcome assessment of pulmonary rehabilitation in traits-based clusters of COPD patients in PLOS ONE.

Building on the previous work with Ingrid Augustin from 2020, we clustered the multidimensional outcome parameters and compared this new clustering to the comprehensive model from 2020 which incorporates pulmonary and extra-pulmonary traits at base assessment. The comprehensive base assessment model has distinct predictive power to forecast probable response patterns.

Find the full open access article at journals.plos.org.

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Horn (NL) / Vienna (AT), 18 November 2021 Viscovery model to reduce disease burden for patients with chronic heart failure

Together with Nicole Uszko-Lencer and her colleagues from our long term customer CIRO+, we published the article Clustering based on comorbidities in patients with chronic heart failure: an illustration of clinical diversity in ESC Heart Failure.

This article analyzes data from 603 patients with chronic heart failure who participated in a specialized heart failure rehabilitation program. Viscovery SOMine is used to find clusters of patients with similar comorbidity profiles, which are then screened for significant differences in extracardiac physical and psychological characteristics.

Find the full open access article at onlinelibrary.wiley.com.